CPSF6 and HIV-1 infection: Fricke et al. showed that TRN-SR2 depletion inhibits HIV-1 infection while simultaneous depletion of CPSF6 and TRN-SR2 rescues HIV-1 infection showing that the ability of TRN-SR2 KD cells to block HIV-1 infection depends on CPSF6 [85].