In an experimental model of HNSCC disseminated tumor cells, it was shown that TGF-β2 and TGF-β-RIII signaling through p38α/β regulated DTC dormancy and determined restrictive (bone marrow) or permissive (lung) microenvironments, therefore suggesting a “seed and soil” mechanism [82]. The gene discussed is TGFB2; the disease is head and neck squamous cell carcinoma.