The multivariable analysis of steatosis revealed severe psoriasis to be an independent risk factor for liver steatosis, with an OR adjusted for age, metabolic syndrome, HCV coinfection, years since diagnosis of HIV, total CD4 cell count, and time of efavirenz exposure of 12 years (95% CI, 1.2–120; p = 0.03). This evidence concerns the gene CD4 and fatty liver disease.