UDP-mediated activation of P2Y6 receptor promotes the recruitment of inflammatory cells to sites of inflammation or infection by inducing the production of various chemokines including CCL2 (monocyte chemotactic protein 1, MCP-1), CXCL8 (IL-8) and CCL20 (macrophage inflammatory protein-3α, MIP-3α) [70,71,72,73,74]. The gene discussed is CXCL8; the disease is infection.