In recombinant 1321N1 astrocytoma cells, P2Y2 agonist induces direct interaction of Src with the SH3 binding sites in the P2Y2 receptor to facilitate Src activation, which then recruits the EGFR into a protein complex with the P2Y2 receptor and allows Src to phosphorylate and activate the EGFR [44]. The gene discussed is EGFR; the disease is astrocytoma (excluding glioblastoma).