For instance, antiviral therapies against HBV and HCV, anti-inflammatory therapy with corticosteroids in alcoholic hepatitis, immunosuppressants and corticosteroids in autoimmune hepatitis, ursodeoxycholic acid and FXR agonists in PBC and vitamin E, obesity surgery and lifestyle change in NASH help in the reversal of fibrosis. This evidence concerns the gene NR1H4 and Obesity.