The objective of this study was to evaluate whether patients with urolithiasis exhibit systemic endothelial dysfunction in comparison with healthy patients through the Celermajer method, along with stone characteristics, serum markers of oxidative stress (MDA), endothelial dysfunction (ADMA, VCAM-1), and inflammation (IL-6 and CRP) in a cross-sectional study of lithiasic and healthy patients. The gene discussed is CRP; the disease is endothelial dysfunction.