In CML cell lines, an AMPK-independent cell death involved AICAr-induced autophagy [12], but our study showed that, although AICAr induced autophagy in parallel with differentiation, AICAr-mediated differentiation did not depend on the presence of key proteins of canonical autophagy pathway [113]. The gene discussed is PRKAA1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.