IDH3A and acute myeloid leukemia: Differentiation therapy of acute promyelocytic leukemia, a particular subtype of AML, with all-trans retinoic acid provides the most successful pharmacological therapy of AML so that the approach of treating cancer cells by differentiation instead of killing is well appreciated, especially after the recent success of AML differentiation with inhibitors of mutated isocitrate dehydrogenase [114].