Of the commonly mutated genes in NK-AML, CEBPA/GATA2, FLT3/WT1, and FLT3/NPM1 were identified as frequently co-occurring events meanwhile mutated CEBPA was mutually exclusive of mutated NPM1 and FLT3. This is of importance to consider when investigating the clinical implications of mutations in these genes. This evidence concerns the gene FLT3 and acute myeloid leukemia.