Similarly, knockdown of LMTK2 inhibited the proliferation of colon cancer cells by inactivating nuclear factor-κB (NF-κB) [49], while LMTK2 silencing repressed the proliferation and invasion of hepatocellular carcinoma cells in vitro through the inhibition of Wnt/β-catenin signalling [50]. This evidence concerns the gene LMTK2 and malignant colon neoplasm.