Furthermore, OS was significantly shorter in patients with IDH wildtype gliomas (2.3 ± 0.3 years, 95%-CI: 1.7–3.0) as compared to IDH mutant gliomas (10.1 ± 0.5 years, 95%-CI: 9.1–11.1; p = 0.003). Here, IDH2 is linked to central nervous system cancer.