Transcriptomic studies performed in Calu-3 cells infected with SARS-CoV-2 described an upregulation of genes mostly enriched in inflammatory-related pathways, including the nuclear factor kappa B (NF-kB) signaling and cytokine-mediated signaling pathways, suggesting that the viral challenge induces inflammatory responses in an early stage of infection [37]. The gene discussed is NFKB1; the disease is infection.