Lack of these abilities carried in the mouse model of pancreatic ductal adenocarcinoma, KPC (K-RasLSL.G12D/+, Trp53R172H/+, Pdx-1-Cre) mouse, which upon the disruption of fascin-1 gene, exhibited less tumor burden, longer survival time, and the later onset of the tumor formation [45]. Here, PDX1 is linked to neoplasm.