Moreover, Liu et al. recognized Tiam1 (T lymphoma invasion and metastasis 1) as the upstream Rac regulators, with the potential to activate fascin-1 in CRC [110,111] Thus, evaluating therapeutic potential of Rac, Taim1, and/or PKCγ for inhibition of fascin-directed reactions can be beneficial [110,111]. Here, AKT1 is linked to colorectal carcinoma.