For example, pathways of platelet activation, signaling and aggregation were enriched, in the upregulated BC dataset, involving proteins such as kininogen-1; plasminogen; alpha-1B-glycoprotein; fibrinogen gamma chain; serotransferrin; alpha-2-macroglobulin; three of which were also associated with the formation of fibrin clot (kininogen-1; fibrinogen gamma chain; mucin-1; alpha-2-macroglobulin). Here, A2M is linked to breast cancer.