Thus, this study was conducted to explore the mitochondrial sequestration of cyclin B1–CDK1 complexes by apigenin that affecting BCL-2/BCL-xL-regulated ER–mitochondria bioenergetics and metabolism is dictated by PI3K–Akt-mediated signaling pathway in NPC cells. The gene discussed is CDK1; the disease is nasopharyngeal carcinoma.