HMGB1 and cancer: In addition to direct cancer-cell killing, NIR-PIT rapidly induces immunogenic cell death (ICD) [15,16], which initiates activation of the adaptive immune response, employing dead-cell-associated antigens, including calreticulin (CRT), adenosine triphosphate (ATP), high-mobility group box 1 (HMGB1), heat shock protein (Hsp) 70, and Hsp90 [17,18,19,20].