Baseline levels of HBsAg (<3 log10 IU/mL) and HBV DNA (<3.3 log10 IU/mL) were associated with a minimal risk of developing HCC after 10–15 years of follow up, with qHBsAg levels as an independent risk factor in HBeAg-negative, treatment-naïve patients, while HBV DNA and ALT levels were better predictors in HBeAg-positive patients [125]. Here, GPT is linked to hepatocellular carcinoma.