GPT and Cirrhosis: In a study following HBeAg-negative patients with normal ALT and an intermediate viral load (3.30–4.20 log10 IU/mL) for an average duration of approximately 16 years, HBcrAg levels >4 log10 U/mL gave a hazard ratio (HR) of 3.22 (95% CI: 1.61–6.47) for cirrhosis risk [74].