DKK3 and neoplasm: Although it was obvious that grade IV comprised the lowest number of methylated cases for GSK3β and highest for DKK3, the Kruskal-Wallis test showed no significant association of methylation patterns of GSK3β (p = 0.235), DKK1 (p = 0.771), and DKK3 (p = 0.723) promoter regions with the tumor malignancy grade.