In PDA cells alone at 24 h, an increase of VEGF and a decrease of MCP1 was measured (Figure 4a), while at 96 h, a decrease of CCL4, CXCL1, IL6, MCP1, TGFβ, and VEGF was found, with no target being investigated showing an increase with plasma exposure at this incubation time. The gene discussed is CCL4; the disease is Patent ductus arteriosus.