Some of these changes are beneficial when it comes to non-tumor-promoting conditions, e.g., the decrease of VEGF, TGFβ, IL6, CXCL1, CXCL9, IL1β [89], and M2-macrophage-inducing IL4 [90], as well as the increase of immuno-supportive and M1-associated IL12p70 and TNFα [91]. This evidence concerns the gene IL4 and neoplasm.