TOP2A and colorectal carcinoma: Among the other cell cycle and p53 signaling pathway genes are DNA topoisomerase 2-alpha (TOP2A) [58], cell division cycle 6 (CDC6) [59,60], nucleolar and spindle associated protein 1 (NUSAP1) [61], centrosomal protein 55 (CEP55) [62], budding uninhibited by benzimidazoles 1 (BUB1) [63], and the mitotic arrest deficient 2 like 1 (MAD2L1) [63], which are known to be differentially expressed in CRC, and are related to the aggressive tumor phenotypes and advanced tumor stages.