Moreover, peptide tyrosine-tyrosine (PYY), calcium-activated chloride channel 4 (CLCA4), hematopoietic cell-specific lyn substrate 1 (HCLS1), ecotropic viral integration site 2B (EVI2B), and cluster of differentiation 48 (CD48) are also some of the genes differentially expressed in CRC tissues [90,118]. Here, HCLS1 is linked to colorectal carcinoma.