Consistent with the hypothesis of an impaired CEC in T2DM, Blanco-Rojo R. and colleagues demonstrated in a prospective setting that HDL CEC normalized to ApoA-I levels was inversely associated to the future development of T2DM in a cohort of more than 400 subjects free from the disease at the baseline [54]. Here, APOA1 is linked to type 2 diabetes mellitus.