This study provided evidence of a promoting effect of the drug on this HDL function, which is not affected by the diabetes status, but it was blunted in T2DM subjects with allele “2” of haptoglobin, a protein associated with HDL whose polymorphism has been associated with impaired HDL functions [122] and increased CV risk in T2DM patients [123]. The gene discussed is HP; the disease is type 2 diabetes mellitus.