Based on our analysis, we found that CCND1/CDK4/PLK1/CD44 signatures were linked with shorter survival percentages in a group of multiple cancer types, including bladder carcinoma, breast cancer, colon adenocarcinoma, glioblastoma multiforme, head and neck cancers, leukemia, NSCLC, and ovarian cancer (Figure 3). The gene discussed is CCND1; the disease is cancer.