Resveratrol, the polyphenolic compound present in red grapes and wine, ameliorates cardiac dysfunction induced by MI/R by activating the Nrf2/ARE pathway and increases the expression of Nrf2 by inducing SIRT1 or inhibiting GSK3β, thus alleviating myocardial oxidative stress, and thereby improving IRI [89,90]. Here, NFE2L2 is linked to myocardial infarction.