In this study, the results revealed that the combination of conventional CEA values with CTC counts (i.e., number of CD45neg EpCAMpos CTCs or CD45neg EpCAMneg cells) can significantly discriminate CRC’s advanced or metastatic status (Figure 5, Figure 6 and Figure 7 and Table 3 and Table 4). This evidence concerns the gene CEACAM5 and colorectal carcinoma.