Using recursive partitioning, we were able to predict gout with a positive predictive value of 0.70 while simultaneously excluding osteoarthritis (negative predictive value of 0.92) and CPPD (negative predictive value of 0.77) in our patient population using only four biomarkers: serum uric acid, sex, arterial hypertension, and serum CRP. The gene discussed is CRP; the disease is gout.