However, BAT activity may be decreased in patients with type 2 familial partial lipodystrophy (FPLD2), whereby cold exposure (2 h intermittent feet immersion, 5 min in/5 min out in cold water at ~4 °C) did not result in 18F-FDG uptake by BAT and differentiated pre-adipocytes obtained from the supraclavicular BAT depots had lower UCP1 levels than control subjects [89]. This evidence concerns the gene UCP1 and familial partial lipodystrophy, Dunnigan type.