BCL2 and plasma cell myeloma: Dexamethasone, for example, is leading to Bcl-2 dependence and sensitization to venetoclax in multiple myeloma by altering the balance between pro- and antiapoptotic Bcl-2 protein members (increased Bim and decreased Mcl-1 vs. Bcl-2 upregulation), making Bcl-2 expression essential for survival [38].