Since high expression of AKR1B10 has been observed in an esophageal squamous cell carcinoma cell line, OE-21 [132], it would be interesting to analyze the expression of AKR1B10 in specimens from patients with squamous cell carcinoma, which is the predominant form of esophageal carcinoma worldwide. Here, AKR1B10 is linked to carcinoma of esophagus.