Kropotova et al. [72] observed a decrease in the expression of mRNAs for the retinoid metabolizing enzymes (AKR1B10, ADH1B, ADH1C, DHRS9, RDH5, and ALDH1A), and suggested that the resultant disturbance to retinoid homeostasis contributes to the progression of CRC. The gene discussed is AKR1B10; the disease is colorectal carcinoma.