Breast cancer RAO-3 cells exhibit elevated AKR1B10 expression [64], and the high expression is observed in situ and in the serum of the patients, suggesting that AKR1B10 expression may be a diagnostic and therapeutic marker [91,92,93,94,95] as well as a poor prognostic factor for breast cancer [91,95] (Table 3). Here, AKR1B10 is linked to breast carcinoma.