Although the role of AKR1B10 in the pathogenesis of atopic dermatitis and type 2 reaction leprosy remains unknown, its overexpression is related to the proliferation and migration of keratinocytes in psoriasis [135] and causes the dysregulation of retinoid metabolism, one of proposed mechanisms contributing to keloid disease [137,138]. The gene discussed is AKR1B10; the disease is psoriasis.