The upregulation of AKR1B10 may be involved in the carcinogenicity and metastasis of NSCLC by activating the ERK signaling pathway [87,89,90], as well as by the detoxification of RCS derived from lipid peroxidation and suppressing the synthesis of retinoic acid [85]. The gene discussed is AKR1B10; the disease is non-small cell lung carcinoma.