AKR1B10 and gastric cancer: However, there has been no mechanistic study relating AKR1B10 with gastric cancer progression, with the exception of Kropotova et al. [77], who suggested that retinoic acid synthesis was dysregulated due to significant decreases in the mRNAs for AKR1B10 and other retinoid-metabolizing enzymes (ADH4, ADH1B, ADH1C, DHRS9, and RDH12).