In addition, AKR1B10 promotes cancer metastasis through activation of the ERK signaling pathway, which stimulates the downstream integrin α5/δ-catenin mediated FAK/Src/Rac1 signaling pathway [93] and increases the expressions of matrix metalloproteinase-2 (MMP2) and vimentin [95]. Here, AKR1B10 is linked to cancer.