In fact, microglia activation contributes to cognitive impairments in a rotenone-induced PD mouse model, and the depletion of microglia using pexidartinib (PLX3397), a tyrosine kinase inhibitor of colony stimulating factor 1 receptor that hinders microglia survival, or inactivation of reactive microglia with minocycline treatment ameliorates the cognitive deficits and neuronal damage [36]. This evidence concerns the gene CSF1R and Cognitive impairment.