On the other hand, in human subjects, administration of Bifidobacterium species has been proved to reduce systemic pro-inflammatory biomarkers, including C-reactive protein and tumor necrosis factor α (TNF-α) in psoriasis patients [59], and supplementation with a mix of Bifidobacterium and Lactococcus strains in pregnant women results in lower incidence of eczema in infants [60]. The gene discussed is TNF; the disease is psoriasis.