Prophylactic subchronic blockade of sEH with tAUCB, which acts to restore brain EET concentration and reduces brain infarct size after transient middle cerebral artery occlusion (MCAO) in mice, an effect elicited in normal mice but even more robust in the setting of DM2 or DM1, leading to the possibility that the “penalty of diabetes” in stroke could be ameliorated by effective sEH blockade [23,24]. The gene discussed is EPHX2; the disease is diabetes mellitus.