SOCS3 and hepatocellular carcinoma: These data showed that HBV-induced mitochondrial ROS production leads to episilencing of SOCS3 gene expression through snail-mediated epigenetic silencing, leading to sustained activation of the IL-6/STAT3 pathway, which ultimately contributes to hepatocarcinogenesis and indicates that SOCS3 is a potential biomarker for clinical prognosis for HCC [99].