Furthermore, Nodale et al. [15] demonstrated deregulated levels of development-related genes in MRKH patients in comparison to healthy women, by observing a significant downregulation of HOXB2 and HOXB5 in most MRKH patients and a strong overexpression of HOXC8 in MRKH type I patients. The gene discussed is HOXC8; the disease is Mayer-Rokitansky-Kuster-Hauser syndrome.