ABCC8 and neoplasm: In the tumor tissue, we revealed the downregulation of radish homologs of genes for glucosinolate biosynthesis enzymes: Cytochrome P450s CYP83A1 and SPS1/BUS1, methylthioalkylmalate synthases IMS3/MAM1 and IMS2/MAM3, isopropylmalate isomerase LEUD1, methionine-oxo-acid transaminase BCAT4, C-S lyase SUR1/ALF1, and 3-isopropylmalate dehydrogenase ATIMD1 [63].