TRPM2 and neurodegenerative disease: Studies have disclosed important physiological roles for the TRPM2 channel, including insulin secretion [49], immune responses [47,50] and warmth sensing [93,94], and also support a critical role for the TRPM2 channel, particularly TRPM2-mediated Ca2+ signaling in linking a diversity of ROS-inducing factors to associated pathologies, including ischemic stroke, neurodegenerative diseases, inflammatory diseases, cancer and diabetes [45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61].