Studies have shown that protein kinase D2/3 (PKD 2/3) of the prostate cancer cells increased infiltrating mast cells through turning on transcription factors, including AP-1 and/or nuclear factor kappa light chain enhancer of activated B cell (NF-κB), to upregulate scf, CCL5, and CCL11 transcripts [12]. This evidence concerns the gene NFKB1 and Familial prostate cancer.