Mice in which Hnrnpu is deleted in striated muscles (Ckm-Cre) die around P14 due to a dilated cardiomyopathy (DCM) phenotype, whereas mice in which Hnrnpu is deleted specifically within cardiomyocytes (Myh6-Cre) die around P10 due to a similar DCM phenotype [301]. This evidence concerns the gene CKM and familial dilated cardiomyopathy.