AKT1 and lung cancer: Although jorunnamycin A-mediated downregulation of Akt signaling has been previously reported in various human lung cancer cells [35], the investigation of CSC-related mechanisms demonstrated the suppression of p-Akt/Akt level only in CSC-enriched H460 spheroids but not in CSC subpopulations derived from H23 (Figure 6C,D) and A549 cells (Figure 6E,F).