Zizzo et al. have previously suggested an inhibitory role for NO in modulating Ang II-induced colonic contraction in the distal colon of DNBS-treated rats [17], and it was reported that NO release from neurons or enteric glia is stimulated by the activation of nicotinic receptors in animals with experimental colitis but by muscarinic receptors in controls [64]. The gene discussed is AGT; the disease is colitis.