MPO and colitis: Our study advances the state-of-the-art and pursues translational relevance in colitis because instead of studying the colon as a uniform target organ of IBD, we studied: (1) the PC—no macroscopic alterations, similar MPO activity but increased wet-to-dry ratio vs. controls; (2) the MC—evident macroscopic alterations and increased MPO activity and wet-to-dry ratio; and (3) the DC—increased MPO activity and wet-to-dry ratio than in controls but more marked MaS than the MC.