The expression of several genes coding for calcium channels has demonstrated to be upregulated in CRC cells, including TRPC1 and TRPM2 [165,166], the activity of which has been related to the promotion of metastases; while TPRM6, the expression of which has been related to better patient survival, has been found to be downregulated in CRC cells [167]. The gene discussed is TRPM2; the disease is colorectal carcinoma.