Although Fn enrichment in stool or epithelial samples is associated with mucosal degeneration, presence of metastases [193,194,200] and chemoresistance [201] and increased risk of disease-specific mortality [202,203], Fn-positive CRCs are more frequently characterized by microsatellite instability [202,204,205], a group of tumors classified as usually having better prognosis than their counterpart microsatellite stable CRC, due to their higher immune infiltrate (TILs) and low metastatic potential [25,110,206]. Here, FN1 is linked to colorectal carcinoma.