Analyses of MEC-1, MCF-7, T-47D, SKBR3 and MDA-MB-231 after treatment with NKExos showed enhanced killing capacity of siBCL-2 compared to siScr NKExos in ER+ MCF-7 and T-47D cells as well as the MEC-1 CLL cells (Figure S2A–C), while MDA-MB-231 and to a lower extent SKBR3 showed Annexin V induction after NKExos treatment, but no differences between siScr and siBCL-2 NKExos (Figure S2D,E). Here, ANXA5 is linked to B-cell chronic lymphocytic leukemia.