First, we did not find significant differences in the RUNX1 jejunal expression according to the presence of NAFLD or according to the hepatic histopathological classification; however, when we analyzed the expression of main lipid metabolism-related genes and TLR in jejunal tissue, we observed that jejunal FXR expression decreases in NAFLD and in NASH. The gene discussed is RUNX1; the disease is metabolic dysfunction-associated steatotic liver disease.