In this regard, our study reported the relative upregulation of the RUNX1 expression in the liver of patients with SS compared to that of patients with NL histology; in addition, we found downregulated RUNX1 expressions in patients with NASH compared to those in patients with SS, which was at a similar level to that found in NL patients. Here, RUNX1 is linked to metabolic dysfunction-associated steatohepatitis.