First, we did not find significant differences in the RUNX1 jejunal expression according to the presence of NAFLD or according to the hepatic histopathological classification; however, when we analyzed the expression of main lipid metabolism-related genes and TLR in jejunal tissue, we observed that jejunal FXR expression decreases in NAFLD and in NASH. Here, NR1H4 is linked to metabolic dysfunction-associated steatohepatitis.