No defect was observed in the magnitude of the SARS-CoV-2 spike-specific CD4+ and CD8+ T cell response in individuals with prolonged COVID-19 symptoms when assessed using flow cytometry, and the transcription profile of SARS-CoV-2-specific CD4+ T cells was observed not to be influenced by the duration of COVID-19 symptoms. This evidence concerns the gene CD4 and COVID-19.