EZH2 and melanoma: Having established that miR-129-5p is induced during BRAFi and MEKi response and mediated by EZH2 downstream of constitutive active BRAF signaling, we subsequently studied the biological function of miR-129-5p on proliferation of BRAF mutated melanoma cells: miR-129-5p overexpression reduced proliferation of melanoma cell line A375, whereas knockdown of miR-129-5p by a miRZip-129-5p construct significantly increased proliferation (Figure 4A).