Our study provides evidences that miR-129-5p acts as a tumor suppressor improving the response to BRAFi and inhibiting the proliferation of melanoma cells by targeting SOX4. Due to these results we conclude that miR-129-5p is an important molecular regulator of response to BRAFi, which is repressed by downstream signaling pathways of constitutively active BRAF in melanoma. This evidence concerns the gene SOX4 and melanoma.