BRAF and esophageal cancer: Since SOX4 controls EZH2 expression by direct promotor binding [79] and SOX4/EZH2 are shown to interact as co-repressors on tumor suppressive miR-31 in invasive esophageal cancer cells [80], we hypothesize a regulatory network in BRAF mutated melanoma, in which constitutively activated BRAF signaling induces SOX4 and EZH2 expression, resulting in miR-129-5p repression (Figure 6).