Low brain ASC altered glutamate clearance and increased oxidative stress and sensitivity for seizure-induction as well as cognitive decline in mice models of Alzheimer’s Disease (svct2+/−-Amyloid precursor protein/Presenelin 1 (APP/PSEN1) mice and gulo−/− APP/PSEN1 mice), linking vitC deficiency to dysregulation of glutamate and concurrent functional consequences [190,194]. This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.