PIGF and Salivary Gland Pleomorphic Adenoma: Furthermore, PLAG1 induction is associated with higher expression of other target genes, such as CRLF1, CRABP2, CRIP2, or PIGF. The ectopic PLAG1 gene expression can trigger the development of lipoblastoma and pleomorphic adenomas of the salivary gland, and its overexpression is frequently observed in hepatoblastoma and AML [66,67].