NBPF14 (Neuroblastoma Breakpoint Family Member 14) is an interesting candidate for a role in microcephaly, not only as it co-evolved with NOTCH2NLB and is located in the chromosomal region that is associated with 1q21.1 distal syndrome [24,25], but also as it belongs to the NBPF gene family. The gene discussed is NOTCH2NLB; the disease is microcephaly.