Furthermore, a high fat-low streptozotocin type 2 diabetic model, which closely mimics type 2 diabetic populations, has shown that even during early stages of diabetes, compared to age-matched normal rats, Rac1-Nox2-ROS are high in type 1 diabetic animals, but type 2 diabetic animals have exacerbated increase in Rac1-Nox2-ROS, compared to type 1 diabetic model [43]. This evidence concerns the gene RAC1 and diabetes mellitus.