SHBG and polycystic ovary syndrome: In conclusion, treatment with the combination of Myo-Ins and D-Chiro-Ins in the 40:1 ratio seems to be the most effective approach for restoring ovulation and normalizing crucial parameters (progesterone, LH, SHBG, estradiol, and testosterone) in overweight and obese PCOS patients [42], also reducing the risk of cardiovascular-related problems.