It is often characterized by a condition of chronic oligo—or anovulation (usually manifested as oligo—or amenorrhea), and hyperandrogenism [3], which derives from elevated serum levels of luteinizing hormone (LH) and a consequent altered ratio between LH and follicle stimulating hormone (FSH) [4,5,6,7]. Here, PLOD1 is linked to hyperandrogenism.