TNF and neoplasm: The effect of NGR-TNF on tumor vasculature permeability, which has been demonstrated by dynamic contrast-enhanced (DCE)-MRI and single-photon emission CT (SPECT) with diethylenetriaminepentaacetic acid tagged with 99mTc (99mTc-DTPA-SPECT), has been more evident in lymphomatous and peritumoral areas [76].