FN1 and neoplasm: In a recent study on high-grade serous ovarian carcinoma (HGSOC), a lower expression of fibulin-5 was noted in the cancerous sample compared with that of the normal sample [131].In pancreatic ductal adenocarcinoma, fibulin-5 promotes tumor progression by blocking the reactive oxygen species production through competing with fibronectin for integrin binding sites, resulting in increased angiogenesis and tumor growth (Figure 4) [132].